...
   hWnd:=DllCall("GetAncestor", "UInt", hWnd
                              , "UInt", 2) ; GA_ROOT
...

^RButton:: ; ctrl + правый клик в иконку гитары
Создает красную рамку вокруг иконки и ждет нажатие клавиши которая будет назначена( Hotkey1). После назначения клавиши перекрашивается в желтую.

Каждый клик создает новую рамку с новым биндом(Hotkey2 , 3...).

Hotkey1::Клик в центр привязанной рамки рамки

Gui, +LastFound
hwnd:=WinExist()
hDesktop:=DllCall("GetDesktopWindow")

VarSetCapacity(RECT,16,0)
VarSetCapacity(XFORM,24,0)
NumPut(1,XFORM,0,"float")
NumPut(1,XFORM,12,"float")
NumPut(1,XFORM,16,"float")
NumPut(1,XFORM,20,"float")
hbr:=DllCall("CreateSolidBrush","uint",0x507fff) ; 0x50a4f4
hrgn:=DllCall("CreateRectRgn","int",0,"int",0,"int",0,"int",0)

DllCall( "RegisterShellHookWindow","uint",hwnd)
MsgNum:=DllCall("RegisterWindowMessage","str","SHELLHOOK")
OnMessage(MsgNum,"ShellMessage")
Return

ShellMessage(wParam,lParam)
  {
    global hwnd
    If (wParam = (HSHELL_WINDOWACTIVATED:=4))
    {
      hwnd:=lParam
      SetTimer, DrawActiveWindowFrame, -1
    }
  }

DrawActiveWindowFrame:
  If (hwnd!=hDesktop)
  {
    If (prevhwnd!=hwnd)
    {
      hdc:=DllCall("GetWindowDC","uint",prevhwnd)
      DllCall("GetWindowRgn","uint",prevhwnd,"uint",hrgn)
      DllCall("CombineRgn","uint",hrgn,"uint",hrgn,"uint",hrgn_2,"int",(RGN_XOR:=3))
      DllCall("RedrawWindow","uint",prevhwnd,"uint",0,"uint",hrgn,"uint",1|2|4|128|256|512|1024)
      DllCall("ReleaseDC","uint",hwnd,"uint",hdc)
      DllCall("DeleteObject","uint",hrgn_2)
    }
    If hwnd
    {
      hdc:=DllCall("GetWindowDC","uint",hwnd)
      DllCall("GetRandomRgn","uint",hdc,"uint",hrgn,"int",4)
      dwCount:=DllCall("GetRegionData","uint",hrgn,"uint",0,"uint",0)
      VarSetCapacity(RgnData,dwCount,0)
      DllCall("GetRegionData","uint",hrgn,"uint",dwCount,"uint",&RgnData)
      hrgn_2:=DllCall("ExtCreateRegion","uint",&XFORM,"uint",dwCount,"uint",&RgnData)
      DllCall("GetWindowRect","uint",hwnd,"uint",&RECT)
      DllCall("OffsetRgn","uint",hrgn_2,"int",-(x_offset:=NumGet(RECT)),"int",-(y_offset:=NumGet(&RECT+4)))
      DllCall("FrameRgn","uint",hdc,"uint",hrgn_2,"uint",hbr,"int",4,"int",4)
      DllCall("ReleaseDC","uint",hwnd,"uint",hdc)
      prevhwnd:=hwnd
    }
  }
Return

Return
Esc::
DllCall("DeleteObject","uint",hrgn)
DllCall("DeleteObject","uint",hbr)
DllCall("DeregisterShellHookWindow","uint",hwnd)
ExitApp

/*
RDW_INVALIDATE = 1
RDW_INTERNALPAINT = 2
RDW_ERASE = 4
RDW_VALIDATE = 8
RDW_NOINTERNALPAINT = 16
RDW_NOERASE = 32
RDW_NOCHILDREN = 64
RDW_ALLCHILDREN = 128
RDW_UPDATENOW = 256
RDW_ERASENOW = 512
RDW_FRAME = 1024
RDW_NOFRAME = 2048
*/

CoordMode, Mouse
ArrayNames:={1:"R2_BLACK"      ,  2:"R2_NOTMERGEPEN"
          ,  3:"R2_MASKNOTPEN" ,  4:"R2_NOTCOPYPEN"
          ,  5:"R2_MASKPENNOT" ,  6:"R2_NOT"
          ,  7:"R2_XORPEN"     ,  8:"R2_NOTMASKPEN"
          ,  9:"R2_MASKPEN"    , 10:"R2_NOTXORPEN"
          , 12:"R2_MERGENOTPEN", 13:"R2_COPYPEN"
          , 14:"R2_MERGEPENNOT", 15:"R2_MERGEPEN"
          , 16:"R2_WHITE"}
r2:=13 ; R2_COPYPEN
BitMapDimension= ; BGRA
(Join
00000000
00000000
00000000
        00000000
        0000ffff
        00000000
                00000000
                00000000
                00000000
)
VarSetCapacity(RECT, 16, 0), VarSetCapacity(POINT,8)
VarSetCapacity(Buffer, nSize:=StrLen(BitMapDimension)//2, 0)
Loop, % nSize
   NumPut("0x"SubStr(BitMapDimension, 2*A_Index-1, 2)
                                    , Buffer, A_Index-1, "UChar")
hbrbm:=DllCall("CreateBitmap", "Int", 3
                             , "Int", 3
                             , "UInt", 1
                             , "UInt", 32
                             , "UInt", &Buffer)
hpatbr:=DllCall("CreatePatternBrush", "UInt", hbrbm)
DllCall("DeleteObject", "UInt", hbrbm)

Ctrl & LButton::
   DllCall("GetCursorPos", "UInt", &POINT)
   hWnd:=DllCall("WindowFromPoint", "UInt", NumGet(POINT)
                                  , "UInt", NumGet(POINT, 4))
   hWnd:=DllCall("GetAncestor", "UInt", hWnd
                              , "UInt", 2) ; GA_ROOT
   DllCall("GetWindowRect", "Ptr", hWnd, "Ptr", &RECT)
   hdc:=DllCall("GetDC", "UInt", 0) ; screen
   DllCall("SetROP2", "UInt", hdc, "Int", r2)
   hrgn:=DllCall("CreateRectRgn", "Int", NumGet(RECT)
                                , "Int", NumGet(RECT, 4)
                                , "Int", NumGet(RECT, 8)
                                , "Int", NumGet(RECT, 12))
   DllCall("FrameRgn", "UInt", hdc
                     , "UInt", hrgn
                     , "UInt", hpatbr
                     , "UInt", 9
                     , "UInt", 9)
   DllCall("ReleaseDC", "UInt", 0
                      , "UInt", hdc)
   DllCall("Sleep", "UInt", 1000)
   DllCall("RedrawWindow", "UInt", 0
                         , "UInt", 0
                         , "UInt", hrgn
                         , "UInt", 0x787)
   DllCall("DeleteObject", "UInt", hrgn)
   Return
Ctrl & WheelUp::TrayTip,, % ArrayNames[r2=16
                        ? r2:++r2=11 ? ++r2:r2]" ("r2 ")"
Ctrl & WheelDown::TrayTip,, % ArrayNames[r2=1
                        ? r2:--r2=11 ? --r2:r2]" ("r2 ")"
Esc::
   DllCall("DeleteObject", "UInt", hpatbr)
   DllCall("DeleteObject", "UInt", hrgn)
   ExitApp